clavulanate การใช้

• Amoxicillin-clavulanate appears less effective than other options.
• Half were given a month of the antibiotic amoxicillin / clavulanate; the other half got an empty pill.
• The agents available for oral therapy are limited and include amoxacillin plus clavulanate, clindamycin, chloramphenicol and metronidazole.
• Oral agents adequate for polymicrobial oral infections include the combinations of amoxicillin plus clavulanate, clindamycin and metronidazole plus a macrolide.
• Augmentin is a combination of amoxicillin, an antibiotic no longer covered by patent protection, and clavulanate, which is aimed at bacterial resistance.
• Alternatively, amoxicillin combined with clavulanate potassium, cephalosporins ( first-generation ) and many others may also be used as an antibiotic treatment.
• To get around this problem, doctors sometimes prescribe a combination drug, amoxicillin plus clavulanate ( Augmentin ), that can knock out the interference.
• Because of increasing resistance to amoxicillin the 2012 guideline of the Infectious Diseases Society of America recommends amoxicillin-clavulanate as the initial treatment of choice for bacterial sinusitis.
• For the treatment of pyelonephritis during pregnancy, and for the treatment of pyelonephritis caused by gram-positive organisms, amoxicillin or amoxicillin-clavulanate potassium is preferred.
• In that study, Augmentin, which combines the antibiotics amoxicillin and clavulanate, wiped out children's ear infections 83 percent of the time, while Zithromax only worked in 49 percent.
• Among these, albendazole, amoxicillin, amoxicillin-clavulanate, allopurinol, mercaptopurine, mupriocin, pyrimethamine, ranitidine, thioguanine, trimethoprim and zidovudine are listed on the World Health Organization's list of essential medications.
• Currently available beta-lactamase inhibitors are effective against Ambler Class A beta-lactamases ( tazobactam, clavulanate, and sulbactam ) or against Ambler Class A, C and some Class D beta-lactamases ( avibactam ).
• Beta-lactamase inhibitors such as clavulanate, sulbactam, and tazobactam " in vitro " inhibit most ESBLs, but the clinical effectiveness of beta-lactam / beta-lactamase inhibitor combinations cannot be relied on consistently for therapy.
• Pfizer acquired an 80-acre site on the outskirts of amoxicillin / clavulanate potassium ) was launched by Beecham; the anti-ulcer treatment Zantac ( ranitidine ) was launched by Glaxo; and the antiviral herpes treatment Zovirax ( aciclovir ) was launched by Wellcome.
• This may consist of a broad spectrum antibiotic such as ampicillin-sulbactam, ticarcillin-clavulanate ( Timentin ), or a cephalosporin ( e . g . ceftriaxone ) and an antibacterial with good coverage ( fluoroquinolone such as ciprofloxacin ) and anaerobic bacteria coverage, such as metronidazole.
• Other drugs such as topical ivermectin and metrifonate have been somewhat successful, but not enough to be significant . [ 2, 5 ] For superinfections, trimethoprim, sulfamethoxazole, metronidazole, amoxicillin, ( with / without clavulanate ) have been used successfully, though these treat only secondary infections.
• For mild-to-moderate community-acquired infections in adults, the agents recommended for empiric regimens are : ticarcillin-clavulanate, cefoxitin, ertapenem, moxifloxacin, or tigecycline as single-agent therapy or combinations of metronidazole with cefazolin, cefuroxime, ceftriaxone, cefotaxime, levofloxacin, or ciprofloxacin.
• If the specific " Klebsiella " in a particular patient does not show antibiotic resistance, then the antibiotics used to treat such susceptible isolates include ampicillin / sulbactam, piperacillin / tazobactam, ticarcillin / clavulanate, ceftazidime, cefepime, levofloxacin, norfloxacin, gatifloxacin, moxifloxacin, meropenem, and ertapenem.
• Antimicrobial regimens for children include an aminoglycoside-based regimen, a carbapenem ( imipenem, meropenem, or ertapenem ), a beta-lactam / beta-lactamase-inhibitor combination ( piperacillin-tazobactam or ticarcillin-clavulanate ), or an advanced-generation cephalosporin ( cefotaxime, ceftriaxone, ceftazidime, or cefepime ) with metronidazole.
• Although the inhibitor-resistant TEM variants are resistant to inhibition by clavulanic acid and sulbactam, thereby showing clinical resistance to the beta-lactam beta lactamase inhibitor combinations of amoxicillin-clavulanate ( Co-amoxiclav ), ticarcillin-clavulanate, and ampicillin / sulbactam, they remain susceptible to inhibition by tazobactam and subsequently the combination of piperacillin / tazobactam.