cnpase การใช้

• CNPase's catalytic core consists of three RNase A.
• CNPase is thought to play a critical role in the events leading up to myelination.
• Deletion of the C-terminus of CNPase or phosphorylation abolish the catalytic activity of microtubule formation.
• CNPase can link tubulin to cellular membranes, and might be involved in the regulation cytoplasmic microtubule distribution.
• CNPase is expressed exclusively by oligodendrocytes in the CNS, and the appearance of CNPase seems to be one of the earliest events of oligodendrocyte differentiation.
• CNPase is expressed exclusively by oligodendrocytes in the CNS, and the appearance of CNPase seems to be one of the earliest events of oligodendrocyte differentiation.
• CNPase is a myelin-associated enzyme that makes up 4 % of total phosphodiester hydrolysis of 2', 3'- cyclic nucleotides to 2'- nucleotides, though a cohesive understanding of its specific physiologic functions are still ambiguous.
• CNPase also associates with microtubules in brain tissue and FRTL-5 thyroid cells, and is reported to have microtubule-associated protein-like activity ( MAP; see MAP2 ), being able to catalyze microtubule formation at low molar ratios.