collagenases การใช้

• Examples of such metalloproteinases are collagenases, gelatinases and stromelysins.
• Even as fibroblasts are producing new collagen, collagenases and other factors degrade it.
• These collagenases break down protein into peptides.
• The two collagenases act synergistically by cleaving tropocollagen ( the'collagen molecule') at different points.
• To migrate, endothelial cells need collagenases and plasminogen activator to degrade the clot and part of the ECM.
• Cleavage occurs at an Xaa + Gly in Vibrio bacteria and at Yaa + Gly bonds in Clostridium collagenases.
• The first step in the process involves the elimination of the organic collagen fraction by the action of bacterial collagenases.
• Similar to that of induced fit by enzyme-substrate interactions, MMPs in the first group, called collagenases, have interstitial collagens.
• These collagenases digest Type-I collagen, Type-II collagen, Type-III collagen, Type-VII collagen and Type-X collagen.
• Enzymatic hyphal invasion, likely using collagenases which are found in'Arthrobotrys', of a trapped nematode is followed by the digestion of contents of the nematode.
• Regarding its structure, Gelatinase B has domains which can bind with gelatin, laminin, and collagens type I and IV-collagenases do not possess these binding domains.
• Apart from fibrinolysis, plasmin proteolyses proteins in various other systems : It activates collagenases, some mediators of the complement system and weakens the wall of the Graafian follicle ( leading to ovulation ).
• Recent studies have revealed that the gene for collagenases could be detected in stains of " Porphyromonas gingivalis ", one of the many endodontic infective agents that are also involved in periodontal disease.
• Also, through the activation of collagenases, ox-LDL contributes to a process which may lead to the rupture of the fibrous plaque Oxidized LDL decreases the availability of endothelial nitric oxide ( NO ), which, in turn, increases the adhesion of monocytes to the endothelium.