crystallin การใช้

• In cardiac muscle, desmin is present in ?B-crystallin.
• Vertebrate epithelial cells which have high concentrations of the protein crystallin.
• In other compound eyes and camera eyes, the material is crystallin.
• The effect was more pronounced in the ?B-1 Crystallin promoter-driven line.
• This is supported by the observation that alpha-crystallin mutations show an association with cataract formation.
• The lens is made of the protein crystallin; the cornea is made of the protein collagen.
• The crystallin contents of the lens capsule were removed but this was found to regenerate within a month.
• And cataracts form when the lens protein alpha-crystallin becomes crosslinked, possibly by copper-generated superoxide.
• The same gene product functions as both a lens crystallin and an enzyme in other non-ocular tissues.
• Berger JW, Vanderkooi JM . Characterization of lens alpha-crystallin tryptophan microenvironments by room temperature phosphorescence spectroscopy.
• However, like ?B-crystallin, it can also function as molecular chaperone and protect against thermal stress.
• This gene encodes a taxon-specific crystallin protein that binds NADPH and has sequence similarity to bacterial ornithine cyclodeaminases.
• One crystallin, for example, is also known from its humbler role as lactate dehydrogenase, an ordinary metabolic enzyme.
• Within the superfamily, ASL is most closely related to ?-crystallin in amino acid sequence and in protein fold structure.
• SOX1 has shown clinical significance in its direct regulation of gamma-crystallin genes, which is vital for lens development in mice.
• There are two ?-crystallin genes ( ?A and ?B ), which are about 55 % identical in amino acid sequence.
• Alpha-crystallin has chaperone-like properties including the ability to prevent the precipitation of denatured proteins and to increase cellular tolerance to stress.
• In the juvenile, the lower first lenses of the eyes contain crystallin, which constitutes 8 to 13 % of the protein present there.
• This C-terminal tail appears in many mammalian sHsps ( e . g . mouse Hsp25, ?A-crystallin ) and has no homology.
• Elevated expression of alpha-B crystallin occurs in many neurological diseases; a missense mutation cosegregated in a family with a desmin-related myopathy.