cyclin การใช้

• Tim Hunt discovered the first cyclin molecule in the early 1980s.
• In mammalian cells, the activating phosphorylation occurs after cyclin binding.
• Cyclin B plays in integral role in many types of cancer.
• In general levels of p53 and cyclin B are negatively correlated.
• Cyclin E is also a useful prognostic marker for lung cancer.
• Cyclin G-associated kinase is a two domain cystolic protein.
• Cyclin D1 has been found to be overexpressed in breast carcinoma.
• E2F promotes cyclin A2 transcription by de-repressing the promoter.
• Nurse called the gene CDK1, for cyclin-dependent kinase 1.
• Different cyclin-CDK combinations determine the downstream proteins targeted.
• Known CDKs, their cyclin partners, and their functions in the human
• With cyclin, two alpha helices change position to permit ATP binding.
• Cyclin B / CDK1 activates CDC25 resulting in a positive feedback loop.
• Cyclin dependent kinases pair up with cyclins to become operational.
• Cyclin levels can easily be determined through immunohistological analysis of tumor biopsies.
• These rare patients can be identified through their elevated cyclin B levels.
• However, not all cancers which overexpress cyclin B are more aggressive.
• In late S phase, cyclin A can also associate with CDK1.
• E2F initiates transcription of cyclin A by de-repressing the promoter.
• FBXW7 encodes F-box proteins which target cyclin E for ubiquitination.