cycloalkynes การใช้

• Cycloalkanes do not contain multiple bonds, whereas the cycloalkenes and the cycloalkynes do.
• More recently, a superior method for generating strained cycloalkynes was developed by Fujita.
• To circumvent the generation of the undesired allene, the Kobayashi method for aryne generation was adapted for the synthesis of cycloalkynes.
• For example, an UAA with an azide side group provides convenient access for cycloalkynes to proteins tagged with this  AHA unnatural amino acid.
• Transannular strain can also be demonstrated in other cyclo-organic molecules, such as lactones, lactams, ethers, cycloalkenes, and cycloalkynes.
• In addition to the elimination-type pathways described, cycloalkynes can also be obtained through the oxidation of cyclic bis-hydrozones with mercury oxide as well as through the thermal decomposition of selenadiazole.
• Ring strain ( ~ 18 kcal / mol ) arises from the deviation of the bond angles from the ideal 180 in order to form an eight-membered ring, the smallest of all cycloalkynes.
• The vinyl iodonium proved to be a particularly useful synthetic precursor to strained cycloalkynes due to its high reactivity which arises from the strong electron withdrawing ability of the positively charged iodine species as well as the leaving group ability of the iodonium.