cyproterone การใช้

• Several reports also state that cyproterone acetate causes liver hyperplasia.
• It also shows some glucocorticoid activity similarly to cyproterone acetate and unesterified cyproterone.
• It also shows some glucocorticoid activity similarly to cyproterone acetate and unesterified cyproterone.
• So-called brake drugs, such as cyproterone acetate, can retard adolescence.
• Cyproterone acetate was developed to overcome this problem.
• It is formed by adding an acetate group to cyproterone, see figure 3.
• A portion of ingested CPA is metabolized by hydrolysis into cyproterone and acetic acid.
• Some examples of widely used and highly-potent antiandrogens include cyproterone acetate and bicalutamide.
• The binding affinity of oxendolone for the AR is far lower than that of cyproterone acetate.
• Unlike the related drug cyproterone acetate, MPA does not appear to be associated with vitamin B12 deficiency.
• Cyproterone has approximately one-third the potency of CPA as an antiandrogen and is devoid of progestogenic activity.
• Similar poor results with the topical route have disappointingly been found for other antiandrogens such as cyproterone acetate and spironolactone.
• Cyproterone acetate is the most commonly used antiandrogen, except in the United States, where it may not be available.
• Cyproterone acetate acts both directly as an antiandrogen in prostate cancer cells and also functions to indirectly decrease serum testosterone levels.
• Also unlike CPA, due to its lack of progestogenic and antigonadotropic activity, cyproterone does not suppress ovulation in women.
• However, antigonadotropic antiandrogens like cyproterone acetate can produce hypoestrogenism, amenorrhea, and osteoporosis in women, among other side effects.
• These NSAAs eventually crossed the blood brain barrier, like cyproterone acetate, leading to a subsequent increase in serum testosterone levels.
• Among others, this class of drugs includes chlormadinone acetate, cyproterone acetate, hydroxyprogesterone caproate, medroxyprogesterone acetate, and megestrol acetate.
• Progestogens that are used as antigonadotropins include chlormadinone acetate, cyproterone acetate, gestonorone caproate, medroxyprogesterone acetate, megestrol acetate, and oxendolone.
• They are also sometimes used as superior alternatives to anti-androgens like spironolactone and cyproterone acetate for suppressing testosterone production in trans women.