cystathionase การใช้

• Cystathionase is also a target for reactive oxygen species.
• Mutations and deficiencies in cystathionase are associated with cystathioninuria.
• Deficiencies in cystathionase activity have also been shown to contribute to glutathione depletion in patients with cancer and AIDS.
• Cystathionase uses pyridoxal phosphate to facilitate the cleavage of the sulfur-gamma carbon bond of cystathionine, resulting in the release of cysteine.
• Excessive levels of H 2 S, due to increased activity of cystathionase, are associated with endotoxemia, acute pancreatitis, hemorrhagic shock, and diabetes mellitus.
• Thus as cystathionase is oxidized, its activity decreases, causing a decrease in cysteine and, in turn, glutathione in the eye, leading to a decrease in antioxidant availability, causing a further decrease in cystathionase activity.
• Thus as cystathionase is oxidized, its activity decreases, causing a decrease in cysteine and, in turn, glutathione in the eye, leading to a decrease in antioxidant availability, causing a further decrease in cystathionase activity.