cytolysins การใช้

• A diverse range of studies has been done on Cytolysins.
• Membrane-damaging toxins exhibit hemolysin or cytolysin activity " in vitro ".
• Tetanolysin belongs to a family of protein toxins known as cytolysins which bind to cholesterol.
• Finally, the formed cytolysin clusters penetrate target cells'membranes and form membrane pores.
• Pore forming cytolysins ( PFCs ) comprise near 65 % of all membrane-damaging cytolysins.
• Pore forming cytolysins ( PFCs ) comprise near 65 % of all membrane-damaging cytolysins.
• During this stage, cytolysins complete transition from water-soluble monomers state into oligomers state.
• Since the 1970s, more than 40 new cytolysins have been discovered and grouped into different families.
• With the help of receptors, cytolysin monomers combines with each other and form clusters of oligomers.
• Cytolysins adopt a stable membrane pore formation, possibly by the penetration of the membrane by the helix.
• Formation of pores by cholesterol-dependent cytolysins ( CDC ) requires the presence of cholesterol in the target cell.
• Cytolysins form pores in the cytoplasmic membrane that allows for the passage of ions and other molecules into the cell.
• Structural studies reveal that MACPF domains are related to cholesterol-dependent cytolysins ( CDCs ), a family of pore forming toxins previously thought to only exist in bacteria.
• Nelfinavir and simple derivatives have been found to inhibit the production of the virulence factor streptolysin S, a cytolysin produced by the human pathogen " Streptococcus pyogenes ".
• Tomita et al . 2004 purified pleurotolysin, a sphingomyelin-specific two-component cytolysin from the basidiocarps of " Pleurotus ostreatus " and studied pore-formation.
• In the second step, cytolysins adhere to target cell membranes by matching the " " receptors are proteins, but they can be other molecules as well, such as lipids or sugars.
• In addition, Sheldon showed that the bacterium Trueperella pyogenes becomes a pathogen in the uterus by secreting a cholesterol-dependent cytolysin that damages stromal cells, once the epithelium is damaged after parturition.
• Nelfinavir and these related molecules did not exhibit detectable antibiotic activity, but did also inhibit the production of other biologically active molecules, including plantazolicin ( antibiotic ), listeriolysin S ( cytolysin ), and clostridiolysin S ( cytolysin ), by other bacteria.
• Nelfinavir and these related molecules did not exhibit detectable antibiotic activity, but did also inhibit the production of other biologically active molecules, including plantazolicin ( antibiotic ), listeriolysin S ( cytolysin ), and clostridiolysin S ( cytolysin ), by other bacteria.