dealkylation การใช้

• Boron tribromide is a classical reagent for the dealkylation of methyl arylethers.
• Many thiols are prepared by reductive dealkylation of thioethers, especially benzyl derivatives and thioacetals.
• They undergo Sommelet Hauser rearrangement and Stevens rearrangement, as well as dealkylation under harsh conditions.
• Recent observations suggest that AidB may bind to double-stranded DNA and take part in its dealkylation.
• In tests with liver microsomes, dealkylation seemed to be mediated by CYP3A4, but other CYP enzymes appear to be involved as well.
• Their individual molecular structure is also responsible for their different duration of action, whereby metabolic breakdown ( such as " N "-dealkylation ) is responsible for opioid metabolism.
• The mechanism of ether dealkylation proceeds via the formation of a complex between the boron center and the ether oxygen followed by the elimination of an alkyl bromide to yield a dibromo ( organo ) borane.
• This enzyme facilitates oxidative dealkylation of the compound to acetaldehyde and 2-chloro-1-( 2, 4-dichlorophenyl ) vinylethylhydrogen phosphate, the latter of which quickly breaks down to acetophenone.
• These enzyme complexes act to incorporate an atom of oxygen into nonactivated hydrocarbons, which can result in either the introduction of hydroxyl groups or N-, O-and S-dealkylation of substrates.
• The mechanism of dealkylation of tertiary alkyl ethers proceeds via the formation of a complex between the boron center and the ether oxygen followed by the elimination of an alkyl bromide to yield a dibromo ( organo ) borane.
• Four transformation products were detected for EHMC upon exposure to UV radiation . 4-methoxybenzaldehyde ( MOBA ) and 4-methoxycinnamic acid are two transformation products of EHMC via dealkylation . The intermediate MOBA is more toxic than EHMC towards the bacteria.
• Phthalimidopropiophenone is not an active stimulant, but is believed to be potentially capable of acting as a prodrug for cathinone when ingested, as similar N-substituted cathinone derivatives have been encountered by law enforcement, and were found to form cathinone " in vivo " by initial hydroxylation of the pyrrolidine ring followed by subsequent dehydrogenation to the corresponding lactam, then by double dealkylation of the pyrrolidine ring to form the primary amine.