deiodinase การใช้

• Deiodinase 3 prevents T 4 activation and inactivates T 3.
• For information on that enzyme family, see Iodotyrosine deiodinase.
• The protein encoded by this gene belongs to the iodothyronine deiodinase family.
• T 4 is converted as required in the tissues by iodothyronine deiodinase.
• Deficiency of deiodinase can mimic hypothyroidism due to iodine deficiency.
• Iodotyrosine deiodinase salvages the iodide from the deiodination of the iodinated tyrosines.
• The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family.
• Dehalogenation in oxidation and hydrolysis; however, iodotyrosine deiodinase uses reductive dehalogenation.
• Deiodinase 1 both activates T 4 to produce T 3 and inactivates T 4.
• Medication and environmental exposures can result in hypothyroidism with changes in deiodinase enzyme activity.
• Iodotyrosine deiodinase contributes to breakdown of thyroid hormones.
• It is also found in three deiodinase enzymes, which convert one thyroid hormone to another.
• The deiodinase thyrocytes from damage by H 2 O 2 produced for thyroid-hormone biosynthesis.
• Deiodinase 2 also plays a significant role in thermogenesis in brown adipose tissue ( BAT ).
• The iodide that is scavenged by iodotyrosine deiodinase is necessary to again synthesize the thyroid hormones.
• Iodotyrosine deiodinase is thus necessary to keep levels of both iodide and thyroid hormones in balance.
• In addition to inhibiting deiodinase enzymes, iopanoic acid is also a substrate of type 1 deiodinase.
• In addition to inhibiting deiodinase enzymes, iopanoic acid is also a substrate of type 1 deiodinase.
• Iopanoic acid underwent monodeiodination in the presence of type 1 deiodinase in a microsomal mouse liver preparation.
• Mutations in the gene encoding iodotyrosine deiodinase can affect enzyme function and be detrimental to human health.