deoxyribonucleotides การใช้

• The reduction of ribonucleotides to deoxyribonucleotides is catalyzed by ribonucleotide reductase.
• Deoxyribonucleotides are nucleotides in which the sugar is deoxyribose.
• Ribonucleotide reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides.
• Activated free deoxyribonucleotides exist in the cell as deoxyribonucleotide triphosphates ( dNTPs ).
• This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides.
• It is the first eukaryotic protein to be identified with priming activity using deoxyribonucleotides.
• DNA ligase then joins the deoxyribonucleotides together, completing the synthesis of the lagging strand.
• In ribonucleotides, the sugar component is ribose while in deoxyribonucleotides, the sugar component is deoxyribose.
• Glutaredoxins function as electron carriers in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase.
• Heading towards the replication fork, the nicks ) are filled with deoxyribonucleotides and sealed by the enzyme ligase.
• Once RNR is inhibited, the cell cannot produce the deoxyribonucleotides required for DNA replication and repair, and cell apoptosis is induced.
• The deoxyribonucleotides used to make DNA are made from ribonucleotides, the building blocks of RNA, by removing the 2'- hydroxyl group.
• The phosphodiester linkage between two ribonucleotides can be broken by alkaline hydrolysis, whereas the linkage between two deoxyribonucleotides is more stable under these conditions.
• Two of the four deoxyribonucleotides ( deoxyadenosine and deoxyguanosine ) and two of the four ribonucleotides ( adenosine, or inhibit the enzymes required for more purine formation.
• This enzyme functions in dephosphorylating nucleoside triphosphates, especially the 52-and 22 ( 32 )-phosphates of uracil and thymine deoxyribonucleotides ( dUMPs and dTMPs ).
• First, an RNA primer is synthesized by primase, and, like that in leading strand synthesis, DNA Pol III binds to the RNA primer and adds deoxyribonucleotides.
• Deoxyribonucleotides in turn are used in the synthesis of UDP . dTDP ( deoxythymidine diphosphate ) is synthesized by another enzyme ( thymidylate kinase ) from dTMP ( deoxythymidine monophosphate ).
• When deoxyribonucleotides polymerize to form DNA, the phosphate group from one nucleotide will bond to the 3'carbon on another nucleotide, forming a phosphodiester bond via dehydration synthesis.
• "' Ribonucleotide reductase "'( RNR ), also known as "'ribonucleoside diphosphate reductase "', is an enzyme that catalyzes the formation of deoxyribonucleotides from ribonucleotides.
• Ribonucleotide reductase ( RNR ) is an essential enzyme for all living organisms since it is responsible for the last step in the synthesis of the four deoxyribonucleotides ( dNTPs ) necessary for DNA replication and repair.