dpdpe การใช้

• Evidence for whether ? agonists produce respiratory depression is mixed; high doses of the ? agonist peptide DPDPE produced respiratory depression in sheep, but in tests on mice the non-peptide ? agonist SNC-80 produced respiratory depression only at the very high dose of 40 mg / kg.
• However, there are now several selective ? opioid agonists available, including peptides such as DPDPE and deltorphin II, and non-peptide drugs such as SNC-80, the more potent ( + )-BW373U86, a newer drug DPI-287, which does not produce the problems with convulsions seen with the earlier agents, and the mixed ? / ? agonist DPI-3290, which is a much more potent analgesic than the more highly selective ? agonists.