dynamin การใช้
- The structure on the right is dynamin in its constricted state.
- The first structure on the left is dynamin in its relaxed state.
- Dynamin is the only molecular motor known to have a twisting activity.
- This constriction is in part the result of the twisting activity of dynamin.
- This gene encodes a member of the dynamin subfamily of GTP-binding proteins.
- Late into the constriction phase, dynamin proteins assemble around the outer plastid-dividing ring,
- This shows the extent to which dynamin tightens and changes when GTP is converted to GDP.
- This condition is now known as dynamin 2 centronuclear myopathy ( abbreviated DNM2-CNM ).
- The OPA1 gene codes for a dynamin-related GTPase protein targeted to the mitochondrial inner membrane.
- This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases.
- Dynamin has been extensively studied in the context of clathrin-coated vesicle budding from the cell membrane.
- However, a single dynamin family member known as OPA1 in mammals mediates fusion between mitochondrial inner membranes.
- :: : See clathrin and dynamin for details on how vesicles are " pinched " off of a membrane.
- Interactions from calcineurin activate dynamin GTPase activity, allowing the clathrin pit to excise itself from the cell membrane and become a cytoplasmic vesicle.
- Dynamin and Eps15 are required for this endocytosis to occur, indicating that anthrax toxin enters the cell via the clathrin-dependent pathway.
- A key protein required for endocytosis is dynamin : It assists in budding a coated pit into a cell to form a coated vesicle.
- Such mutant flies have the property that, when the fly is brought from its normal 22癈 to 30癈, the dynamin function is lost.
- Additionally, the protein has binding sites for endophilin 3 and dynamin 2 at amino acids 89-100 and 195-214, respectively.
- This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2.
- Dynamin itself is a 96 kDa enzyme, and was first isolated when researchers were attempting to isolate new microtubule-based motors from the bovine brain.
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