ehts การใช้

• Therefore, EHTs are suitable to model the disease phenotype and recapitulate functional alterations found in mice with hypertrophic cardiomyopathy.
• Disease-modeling by engineered heart tissue ( "'EHT "') technology with cardiac cells from heterozygous or homozygous " Mybpc3 "-targeted knock-in mice reproduced observations made in human and mouse studies displaying abbreviated contractions, greater sensitivity to external Ca2 + and smaller inotropic responses to various drugs ( isoprenaline, EMD 57033 and verapamil ) compared to wild-type control EHTs.