elastase การใช้

• Pancreatic elastase is a compact globular protein with a hydrophobic core.
• Other useful markers of infection are seminal elastase and seminal cytokines.
• Human pancreatic elastase 1 ( E1 ) remains undegraded during intestinal transit.
• Cathepsin S may be considered the most potent elastase known.
• The gene encoding neutrophil elastase, ELA2, consists of five exons.
• Hence this enzyme has been renamed as elastase-1.
• Pancreatic elastase is formed by activation of proelastase from mammalian pancreas by trypsin.
• Elastase 3B may also function in the intestinal transport and metabolism of cholesterol.
• Elastase 3A may also function in the intestinal transport and metabolism of cholesterol.
• To date, elastase 1 expression has only been detected in skin keratinocytes.
• Normally the elastase might help break down damaged tissues so that repair could occur.
• There appear to be two forms of neutrophil elastase, termed IIa and IIb.
• Elastase 3B preferentially cleaves proteins after alanine residues.
• Elastase 3A preferentially cleaves proteins after alanine residues.
• However unlike other elastases, pancreatic elastase 1 is not expressed in the pancreas.
• Acid proteinases, elastase, keratinases, and other proteinases reportedly act as virulence factors.
• In order to minimize damage to tissues, there are few inhibitors of neutrophil elastase.
• Reaction catalysed by pancreatic elastase 1.
• Thus the quantification of pancreatic elastase 1 in serum allows diagnosis or exclusion of acute pancreatitis.
• Levels of fecal elastase lower than 200 ?g / g of stool indicate an exocrine insufficiency.