enalaprilat การใช้

• Enalaprilat was developed partly to overcome these limitations of captopril.
• Enalaprilat, however, had a problem of its own.
• Thus, enalaprilat was only suitable for intravenous administration.
• This was overcome by the esterification of enalaprilat with ethanol to produce enalapril.
• Peak plasma enalaprilat concentrations occur 2 to 4 hours after oral enalapril administration.
• Enalaprilat, however, had a problem of its own in that it had poor oral availability.
• This was overcome by the researchers at Merck by the esterification of enalaprilat with ethanol to produce enalapril.
• Scientists at Merck created lisinopril by systematically altering each structural unit of enalaprilat, substituting various amino acids.
• As a prodrug, enalapril is metabolized " in vivo " to the active form enalaprilat by various esterases.
• Renal impairment [ particularly creatinine clearance < 20 ml / min ( < 1.2 L / h ) ] results in significant accumulation of enalaprilat and necessitates dosage reduction.