epinine การใช้

• Thus it is believed that epinine is the pharmacologically active moiety.
• Epinine has been found in plants, insects and animals.
• The pharmacology of epinine largely resembles that of its " parent ", dopamine.
• Ibopamine can be rapidly hydrolysed to epinine which is the active molecule responsible for the mydriatic effect.
• The epinine, an analogue of dopamine, can stimulate dopamine receptors and to a lesser degree adrenergic receptors.
• After being hydrolysed to epinine, ibopamine is able to stimulate the alpha-adrenergic and D1 dopaminergic receptors, thereby exhibiting mydriatic effects.
• These studies, conducted using anesthetized animals, were amplified by van Woerkens and co-workers, who compared the effects of epinine and dopamine in unanesthetized pigs, so as to avoid any possible influences of an anesthetic.
• Eventually, epinine was determined to be a non-selective stimulant of dopamine ( DA ) receptors, ?-, and ?-adrenoceptors, with the stimulation of D 2 receptors leading to inhibition of noradrenergic and ganglionic neurotransmission.
• "' Deoxyepinephrine "', also known by the common names "'N-methyldopamine "'and "'epinine "', is an organic compound and natural product that is structurally related to the important neurotransmitters dopamine and epinephrine.
• The results of these experiments showed that, in pigs, over the dose-range employed, epinine was more potent than dopamine as an agonist on D 2, ?-, and ? 2-receptors, but was weaker than dopamine as a D 1-agonist.