extrahepatic การใช้

• The choroid plexus is an established extrahepatic expression site.
• Both CYP3A4 and CYP3A5 are expressed in liver and intestine, with CYP3A5 being the predominant form expressed in extrahepatic tissues.
• Estradiol is metabolized primarily in the liver by CYP3A4 and other cytochrome enzymes, and to a lesser extent in extrahepatic tissues.
• This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway of extrahepatic tissues, which converts cholesterol to bile acids.
• Extrahepatic vessels found on angiographic evaluation are often embolized in order to prevent nontarget deposition of microspheres, that can lead to gastrointestinal ulceration.
• They are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts.
• The three main lines of research of his Unit at IMIM are : 1 ) Clinical and molecular epidemiology of pancreatic cancer and cancer of the extrahepatic biliary system.
• Also, due to an increased demand for liver transplantation together with an augmented risk of liver failure following large resections, development of detoxifying extrahepatic systems are necessary.
• People with PBC may also sometimes have the findings of an associated extrahepatic autoimmune disorder such as rheumatoid arthritis or Sj鰃ren's syndrome ( in up to 80 % of cases ).
• The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A ( CoA ) from succinyl-CoA to acetoacetate.
• HBV-preS-specific receptors are expressed primarily on hepatocytes; however, viral DNA and proteins have also been detected in extrahepatic sites, suggesting that cellular receptors for HBV may also exist on extrahepatic cells.
• HBV-preS-specific receptors are expressed primarily on hepatocytes; however, viral DNA and proteins have also been detected in extrahepatic sites, suggesting that cellular receptors for HBV may also exist on extrahepatic cells.
• Discrete localized enlargements of normal structures ( ureters, blood vessels, intrahepatic or extrahepatic biliary ducts, pulmonary inclusions, or gastrointestinal duplications ) due to outflow obstructions or narrowings, or abnormal connections, may also present as a tumor.
• The catechol estrogens are formed from estradiol and estrone by cytochrome P450 enzymes predominantly in the liver but also in extrahepatic tissues, and are reactive quinones and semiquinones, and this has been hypothesized to contribute to estrogen-induced carcinogenesis.
• Project supervisor Wong, 36, will donate part of his liver to his daughter whose abdomen is distended due to fluid accumulation as a result of the congenital condition called " extrahepatic biliary atresia " where the bile duct that drains bile from the liver to the intestines does not exist.
• Whereas 4-hydroxylation constitutes the minor pathway in the liver, the greater proportion of CYP1B1 expression in extrahepatic tissues shifts the balance in favor of 4-OH-E 2 formation . 4-OH-E 2 is thought to be the most carcinogenic of all the estradiol metabolites, especially considering that CYP1B1 exhibits overexpression in breast cancer tumors.
• Two of the immediate metabolites of testosterone, 5?-DHT and estradiol, are biologically important and can be formed both in the liver and in extrahepatic tissues . 5?-Reductase is highly expressed in the male reproductive organs ( including the prostate gland, seminal vesicles, and epididymides ), skin, hair follicles, and brain and aromatase is highly expressed in adipose tissue, bone, and the brain.
• There are a number of staging classifications for HCC available however due to the unique nature of the carcinoma in order to fully encompass all the features that affect the categorization of the HCC, a classification system should incorporate; tumor size and number, presence of vascular invasion and extrahepatic spread, liver function ( levels of serum bilirubin and albumin, presence of ascites and portal hypertension ) and general health status of the patient ( defined by the ECOG classification and the presence of symptoms ).