farnesol การใช้

• Farnesol is produced from 5-carbon isoprene compounds in both plants and animals.
• This biosynthesis can be mimicked in the laboratory by preparing allylic stanane from farnesol, termed Corey synthesis.
• Phosphate activated derivatives of farnesol are the building blocks of most, and possibly all, acyclic sesquiterpenoids.
• As such, farnesol and its derivatives are important starting compounds for both natural and artificial organic synthesis.
• From these gardens are derived the names of Acacia farnesiana and from its floral essence, the important biochemical farnesol.
• Some important prenylation chains that are involved in the HMG-CoA reductase metabolic pathway are geranylgeraniol, farnesol and dolichol.
• "' Farnesol "'is a natural 15-carbon organic compound which is an acyclic sesquiterpene alcohol.
• In a 1994 report released by five top cigarette companies, farnesol was listed as one of 599 additives to cigarettes.
• It contains proteins, lipids ( notably cholesterol ), phenols, cresols and sesquiterpenes ( notably farnesol and its derivatives ).
• Normally, lamin A is recognized by ZMPSTE24 ( FACE1, a metalloprotease ) and cleaved, removing the farnesol and a few other amino acids.
• The period for " frq " null mutants varied from 12 to 35 hours but could be stabilized by the addition of farnesol or geraniol.
• After being translated, a farnesol is added to prelamin A using protein farnesyltransferase; this farnesylation is important in targeting lamin to the nuclear envelope, where it maintains its integrity.
• This enzyme belongs to the family of isomerases, specifically systematic name of this enzyme class is "'2-trans, 6-trans-farnesol 2-cis-trans-isomerase " '.
• "' Indometacin farnesil "'( INN ) is a prodrug of the non-steroidal anti-inflammatory drug indometacin, designed to reduce the occurrence of side-effects by esterification of the carboxyl group on indometacin with farnesol.
• They concluded suppression of mevalonate pathway activities, be it by modulators of HMG CoA reductase ( statins, tocotrienols, and farnesol ), farnesyl transferase ( farnesyl transferase inhibitors ), and / or mevalonate pyrophosphate decarboxylase ( phenylacetate ) activity, have a potential in pancreatic cancer chemotherapy.
• While the vast majority of farnesyl diphosphate is converted into ultimately cholesterol in animals, in insects it is apparently acting on by a diphosphatase to give farnesol, which in turn is acted on by an NAD + dependent enzyme, farnesol / farnesal dehydrogenase in " M . sexta " and to also be present in mosquitoes.
• While the vast majority of farnesyl diphosphate is converted into ultimately cholesterol in animals, in insects it is apparently acting on by a diphosphatase to give farnesol, which in turn is acted on by an NAD + dependent enzyme, farnesol / farnesal dehydrogenase in " M . sexta " and to also be present in mosquitoes.
• While chamomile exhibits some anti-inflammatory effects by itself, it is not recommended that it be taken concurrently with Aspirin or non-salicylate NSAIDs ( non-steroidal anti-inflammatory drugs ) as it is unknown if a clinically significant herb-drug interaction exists . " Chamomile consists of several ingredients including coumarin, glycoside, heniarin, flavonoid, farnesol, nerolidol and germacranolide.
• Further research efforts of Pluh醨 Zs . et al . on the volatile oil composition of " T . pannonicus " from nineteen different localities of Hungary, confirmed a significant essential oil polymorphism in this plant species, as twelve different chemovarieties were determined, namely : thymol, thymol / p-cymene, thymol / p-cymene / ?-terpinene, thymol / p-cymene / neral, thymol / p-cymene / ?-terpinene / ?-bisabolene, thymol / p-cymene / isoborneol / ?-terpinene, thymol / linalyl acetate / ?-terpinene / ?-cubebene, p-cymene / geraniol / linalyl acetate, linalyl acetate / geranyl acetate, germacrene-D / ?-caryophyllene, caryophyllene oxide / ?-cubebene / linalool, and germacrene-D / ?-caryophyllene / farnesol.