favism การใช้

• These manifestations may be life threatening, especially favism in children.
• However, not all individuals with G6PD deficiency show favism.
• All individuals with favism show G6PD deficiency.
• :: Rice is one of the worst possible foods for diabetics, see also favism.
• Other than this, the specifics of the chemical relationship between favism and G6PD are not well understood.
• These results suggest that divicine is a direct-acting hemolytic agent and likely the direct cause of favism.
• Favism is known to be more prevalent in infants and children, and G6PD genetic variant can influence chemical sensitivity.
• "' Favism "'may be formally defined as a hemolytic response to the consumption of broad beans.
• The convicine, isouramil, divicine and vicine in quantities sufficient to lower glutathione levels in G6PD-deficient persons to cause favism disease.
• Vicine is toxic, causing the disease favism, in individuals who have a hereditary loss of the enzyme glucose-6-phosphate dehydrogenase.
• In the same study, glutathione reductase deficiency was associated with cataracts and favism in one patient and their family, and with severe unconjugated hyperbilirubinemia in another patient.
• It has been suggested that the prohibition of beans was to avoid favism; susceptible people may develop hemolytic anemia as a result of eating beans, or even of walking through a field where bean plants are in flower.
• Favism fit with Bowman s lifelong focus on inherited blood diseases and led to a series of important discoveries about the genetics of these diseases and the populations they affect, especially in the Middle East, Africa and America.
• In Favism, patients lack glucose-6-phosphate dehydrogenase, an enzyme in their pentose phosphate pathway that reduces NADP + to NADPH while catalyzing the conversion of glucose-6-phosphate to 6-phosphoglucono-?-lactone.
• Some epidemiological and " in vitro " studies suggest the hemolysis resulting from favism acts as protection from malaria, because certain species of malarial protozoa, such as " Plasmodium falciparum ", are very sensitive to oxidative damage due to deficiency of the glucose-6-phosphate dehydrogenase enzyme, which would otherwise protect from oxidative damage via production of glutathione reductase.