galectins การใช้

• Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains.
• Companies have developed galectin modulators that block the binding of galectins to carbohydrate structures.
• Galectins in general lack a traditional signal sequence, but are still secreted across the plasma membrane.
• The roles of galectins and galectin-3, in particular, in cancer have been heavily investigated.
• The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell cell and cell matrix interactions.
• The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions.
• The galectins have been implicated in many essential functions including development, differentiation, cell-cell matrix interaction, growth regulation, apoptosis, and RNA splicing.
• Galectin Therapeutics in the United States is also using galectins for their research, finding recently that inhibition of galectin-3 significantly reduces portal hypertension and fibrosis in mice.
• He is also a co-Editor of Handbook of Glycomics, which provides a comprehensive overview of the emerging field of glycomics, and a co-Editor of Galectins : Methods and Protocols.
• LAMP2, along with LAMP1, interact with E-selectin and galectins to mediate the adhesion of some cancer cells to the ECM . The two LAMP molecules act as ligands for the cell-adhesion molecules.
• Galectin-3 is approximately 30 kDa and, like all galectins, contains a carbohydrate-recognition-binding domain ( CRD ) of about 130 amino acids that enable the specific binding of ?-galactosides.
• Indeed, the adhesion of some cancer cells to the extracellular matrix is mediated by interactions between LAMP1 and LAMP2 and E-selectin and galectins, with the LAMPs serving as ligands for the cell-adhesion molecules.