ganglioglioma การใช้
- The glial component of ganglioglioma includes fibrillary astrocytes with varying degrees of cellular atypia.
- In fact, radiation therapy may induce malignant transformation of a recurrent ganglioglioma several years later.
- It is nearly impossible to differentiate ganglioglioma from other more common intramedullary neoplasms based on imaging alone.
- Definitive treatment for ganglioglioma requires gross total surgical resection, and a good prognosis is generally expected when this is achieved.
- Histologically, ganglioglioma is composed of both neoplastic glial and ganglion cells which are disorganized, variably cellular, and non-infiltrative.
- The presence of neoplastic ganglion cells forming abnormal clusters, the presence of binucleation and dysmorphic neurons are helpful clues favoring ganglioglioma over glioma.
- With the exception of WHO grade III anaplastic ganglioglioma, radiation therapy is generally regarded to have no role in the treatment of ganglioglioma.
- With the exception of WHO grade III anaplastic ganglioglioma, radiation therapy is generally regarded to have no role in the treatment of ganglioglioma.
- Astrocytoma and ependymoma are more familiar intramedullary tumors which share many similar features to ganglioglioma, including T2 hyperintensity, enhancement, tumoral cysts, and cord edema.
- Hemangioblastoma and paraganglioma are less usual intramedullary tumors, but since they are more frequently encountered than ganglioglioma, they should also be included in the differential diagnosis.
- In that study, patients with spinal cord ganglioglioma had a 3.5-fold higher relative risk of tumor recurrence compared to patients with supratentorial ganglioglioma.
- In that study, patients with spinal cord ganglioglioma had a 3.5-fold higher relative risk of tumor recurrence compared to patients with supratentorial ganglioglioma.
- Adjuvant chemotherapy is also typically reserved for anaplastic ganglioglioma, but has been used anecdotally in partially resected low grade spinal cord gangliogliomas which show evidence of disease progression.
- According to a series by Lang et al ., reviewing several patients with resected spinal cord ganglioglioma, the 5-and 10-year survival rates after total resection were 89 % and 83 %, respectively.