gyrase การใช้

• There has been some confusion about the role DNA gyrase plays in decatenation.
• As with CcdB the toxin target is DNA gyrase.
• MurI s ability to inhibit gyrase binding can proceed independently of its main function.
• It is believed that eukaryotic cells do not contain DNA gyrase or topoisomerase IV.
• Quinolones are antibacterial agents that act at the level of DNA by inhibiting DNA Gyrase.
• Gyrase ( a form of topoisomerase ) relaxes and undoes the supercoiling caused by helicase.
• Gyrase is most commonly found upstream of the replication fork, where the supercoils form.
• Both gyrase and topoisomerase IV CTDs bend DNA, but only gyrase introduces negative supercoils.
• Both gyrase and topoisomerase IV CTDs bend DNA, but only gyrase introduces negative supercoils.
• Glutamate racemase performs the additional function of gyrase inhibition, preventing gyrase from binding to DNA.
• Glutamate racemase performs the additional function of gyrase inhibition, preventing gyrase from binding to DNA.
• The ability of gyrase to relax positive supercoils comes into play during DNA replication and prokaryotic transcription.
• DNA Gyrase is an enzyme used to unwind double stranded DNA which is essential to DNA Replication.
• The eukaryotic topo II, bacterial gyrase, and bacterial topo IV belong to the type II.
• Confusion arises when some scientific literature state that DNA gyrase is the sole enzyme responsible for decatanation.
• Mutations in DNA gyrase are commonly associated with antibiotic resistance in " P . aeruginosa ".
• While antibacterial compounds such as ciprofloxacin target bacterial gyrase, they fail to inhibit eukaryotic type IIA topoisomerases.
• In this particular experiment, when DNA gyrase alone were inhibited, most of the catenanes were unlinked.
• Fourth generation fluoroquinolones act at DNA gyrase and topoisomerase IV . This dual action slows development of resistance.
• It is responsible for killing plasmid-free segregants, and interferes with the activity of DNA gyrase.