hmwk การใช้

• HMWK is an alpha-globulin with six functional domains.
• HMWK in turn is cleaved by the enzyme kallikrein to produce bradykinin.
• HMWK is a strong inhibitor of cysteine proteinases.
• HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system.
• HMWK is also a precursor of bradykinin; this vasodilator is released through positive feedback by kallikrein.
• Factor XI ( FXI ) is produced by the liver and circulates as a HMWK, prekallikrein, factor XII, factor XI, and factor IX ).
• Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK . In contrast to HMWK, LMWK is not involved in blood coagulation.
• Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK . In contrast to HMWK, LMWK is not involved in blood coagulation.
• Kininogen-1 is the precursor protein to high-molecular-weight kininogen ( HMWK ), low-molecular-weight kininogen ( LMWK ), and bradykinin.
• The KNG1 gene uses alternative splicing to generate two different proteins : high-molecular-weight kininogen ( HMWK ) and low-molecular-weight kininogen ( LMWK ).
• HMWK is not enzymatically active, and functions only as a cofactor for the activation of kallikrein and factor XII . It is also necessary for the activation of factor XI by factor XIIa.
• Measurement of HMWK is usually done with mixing studies, in which plasma deficient in HMWK is mixed with the patient's sample and a partial thromboplastin time ( PTT ) is determined.
• Measurement of HMWK is usually done with mixing studies, in which plasma deficient in HMWK is mixed with the patient's sample and a partial thromboplastin time ( PTT ) is determined.
• HMWK is inactive until it either adheres to binding proteins beneath an endothelium disrupted by injury, thereby initiating coagulation; or it binds to intact endothelial cells or platelets for functions other than coagulation.
• Its current accepted name is to contrast it with " low " molecular weight kininogen ( LMWK ) which has a similar function to HMWK in the tissue ( as opposed to serum ) kinin-kallikrein system.
• In the past, HMWK has been called HMWK-kallikrein factor, Flaujeac factor ( 1975 ), Fitzgerald factor ( 1975 ), and Williams-Fitzgerald-Flaujeac factor,-the eponyms being for people first reported to have HMWK deficiency.
• In the past, HMWK has been called HMWK-kallikrein factor, Flaujeac factor ( 1975 ), Fitzgerald factor ( 1975 ), and Williams-Fitzgerald-Flaujeac factor,-the eponyms being for people first reported to have HMWK deficiency.
• In the past, HMWK has been called HMWK-kallikrein factor, Flaujeac factor ( 1975 ), Fitzgerald factor ( 1975 ), and Williams-Fitzgerald-Flaujeac factor,-the eponyms being for people first reported to have HMWK deficiency.
• HMWK is one of four proteins which interact to initiate the "'contact activation pathway "'( also called the "'intrinsic pathway "') of coagulation : the other three are Factor XII, Factor XI and prekallikrein.
• "' High molecular weight kininogen "'( "'HMWK "'or "'HK "') is a circulating plasma protein which participates in the initiation of blood coagulation, and in the generation of the vasodilator bradykinin via the Kallikrein-kinin system.