hydroxydopamine การใช้

• Such drugs include bretylium, guanethidine and 6-hydroxydopamine.
• It is used as a neurotoxin by neurobiologists to selectively kill serotonergic neurons for research purposes, in the same way that 6-hydroxydopamine is used to kill dopaminergic neurons.
• In an animal model of Parkinson's disease where dopaminergic neurons have been damaged by 6-hydroxydopamine, infusion of TGF-? into the brain caused an increase in the number of neuronal precursor cells.
• For example 6-hydroxydopamine given systemically will selectively kill midbrain dopaminergic neurons and noradrenergic neurons, because it is taken up by the dopamine transporter and noradrenaline transporter, so only neurons expressing these transporters will uptake it.
• In addition, 7, 8-DHF possesses powerful antioxidant activity independent of its actions on the TrkB receptor, and protects against glutamate-induced excitotoxicity, 6-hydroxydopamine-induced dopaminergic neurotoxicity, and oxidative stress-induced genotoxicity.
• LY-503, 430 produces both nootropic and neuroprotective effects, reducing brain damage caused by 6-hydroxydopamine or MPTP and also increasing levels of the neurotrophic factor BDNF in the brain, particularly in the substantia nigra, hippocampus and striatum.
• The mechanism behind this effect isn't well-understood, but many believe ( without clear substantiation ) that it selectively kills serotonergic neurons, in a similar way that 6-hydroxydopamine ( 6-OHDA ) is used to kill dopaminergic cells.
• From a pathological perspective, in a neuronal cell model, dominant-negative MARCH5 prevents mitochondrial fragmentation during neurodegenerative stress induced by the neuron-specific reactive oxygen generator 6-hydroxydopamine, the complex I inhibitor rotenone or Alzheimer's-related amyloid beta peptide.
• Lesion studies have been preformed to measure the direct effects of amphetamine on certain brain areas and their involvement in reinforcement . 6-Hydroxydopamine ( 6-OHDA ) lesions were made to the nucleus accumbens and there was a lack of conditioned place preference shown to amphetamine.
• "' 2, 4, 5-Trihydroxymethamphetamine "'( "'THMA "') is a neurotoxin and a metabolite of MDMA . It has structural similarity to the dopamine neurotoxin 6-hydroxydopamine, and produces lasting serotonin deficits when administered centrally.
• "' Oxidopamine "', also known as "'6-hydroxydopamine "'( "'6-OHDA "') or "'2, 4, 5-trihydroxyphenethylamine "', is a neurotoxic synthetic organic compound used by researchers to selectively destroy dopaminergic and noradrenergic neurons in the brain . 6-OHDA is thought to enter the neurons via the dopamine and noradrenaline ( norepinephrine ) reuptake transporters.