hyperinsulinism การใช้

• Clinical features and circumstances can provide other indirect evidence of hyperinsulinism.
• Some forms of congenital hyperinsulinism respond to diazoxide or octreotide.
• The first case of hyperinsulinism due to a tumor of this type was reported in 1927.
• The gene encoding the channel is called KCNJ11 and mutations in this gene are associated with congenital hyperinsulinism.
• Hyperinsulinism has also been implicated as a contributing factor in the excessive production of androgens in polycystic ovary syndrome.
• Dr . Seale Harris first diagnosed hyperinsulinism in 1924 and also is credited with the recognition of spontaneous hypoglycemia.
• Three subtypes of CDG I ( a, b, d ) can cause congenital hyperinsulinism with hyperinsulinemic hypoglycemia in infancy.
• For instance, babies with neonatal hyperinsulinism are often large for gestational age and may have other features such as enlarged heart and liver.
• In more severe cases of persistent congenital hyperinsulinism unresponsive to drugs, a near-total pancreatectomy may be needed to prevent continuing hypoglycemia.
• When congenital hyperinsulinism is due to focal defects of the insulin-secretion mechanism, surgical removal of that part of the pancreas may cure the problem.
• Dr . Stephen Gyland of Tampa, Florida, suffered from hyperinsulinism and happened on Harris's article in the Journal of the American Medical Association.
• Glucose requirements above 10 mg / kg / minute in infants, or 6 mg / kg / minute in children and adults are strong evidence for hyperinsulinism.
• "' Congenital hyperinsulinism "'is a medical term referring to a variety of congenital disorders in which hypoglycemia is caused by excessive insulin secretion.
• His research on hyperinsulinism and its control brought international recognition to Harris, including the Distinguished Service Medal, the highest scientific award of the American Medical Association.
• Surgical removal of the overactive part of the pancreas is curative with minimal risk when hyperinsulinism is focal or due to a benign insulin-producing tumor of the pancreas.
• The principal treatments of hyperinsulinism due to insulin resistance are measures that improve insulin sensitivity, such as weight loss, physical exercise, and drugs such as thiazolidinediones or metformin.
• Diazoxide also inhibits the secretion of insulin from the pancreas, thus it is used to counter hypoglycemia in disease states such as insulinoma ( a tumor producing insulin ) or congenital hyperinsulinism.
• These studies led to research on the effects in nondiabetic patients of an excessive secretion of insulin and his recognition that hyperinsulinism could cause hypoglycemia, a deficiency of sugar in the blood.
• When congenital hyperinsulinism is diffuse and refractory to medications, near-total pancreatectomy may be the treatment of last resort, but in this condition is less consistently effective and fraught with more complications.
• Insulin levels above 3 ?U / mL are inappropriate when the glucose level is below 50 mg / dL ( 2.8 mM ), and may indicate hyperinsulinism as the cause of the hypoglycemia.