hyperlipoproteinemia การใช้

• Type I hyperlipoproteinemia usually presents in childhood with eruptive xanthomata and abdominal colic.
• Defects in APOE result in familial dysbetalipoproteinemia aka type III hyperlipoproteinemia ( HLP III ), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron, VLDL and LDL remnants.
• This pathology, however, is the second-most common disorder of the various hyperlipoproteinemias, with individuals with a heterozygotic predisposition of one in every 500 and individuals with homozygotic predisposition of one in every million.
• Through catalysis, VLDL is converted to IDL and then to LDL . Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism.
• As PCSK9 binds to LDLR, which prevents the removal of LDL-particles from the blood plasma, several studies have determined the potential use of PCSK9 inhibitors in the treatment of hyperlipoproteinemia ( commonly called hypercholesterolemia ).
• "' Familial dysbetalipoproteinemia "'or type III hyperlipoproteinemia ( also known as " remnant hyperlipidemia ", " remnant hyperlipoproteinaemia ", " broad beta disease " ) is a condition characterized by increased total cholesterol and triglyceride levels, and decreased HDL levels.
• Examples of pathognomonic findings include Koplik's spots inside the mouth in measles, the palmar xanthomata seen on the hands of people suffering from hyperlipoproteinemia, Negri bodies within brain tissue infected with rabies, or a tetrad of rash, arthralgia, abdominal pain and kidney disease in a child with Henoch Sch鰊lein purpura.
• For example, familial hypercholesterolemia ( Type IIa hyperlipoproteinemia ) may be associated with xanthelasma palpebrarum ( yellowish patches underneath the skin around the eyelids ), arcus senilis ( white or gray discoloration of the peripheral cornea ), and xanthomata ( deposition of yellowish cholesterol-rich material ) of the tendons, especially of the fingers.