idiotype การใช้

• The word " idiotype " became influential in immunology when Niels Jerne formulated his immune network theory.
• The engraved inner portions of idiotype ( encircled region no . 5 ) is the paratope where the epitope of the antigen binds.
• He defined idiotype as the set of epitopes on the V region of an antibody molecule, where epitope means an antigenic determinant.
• Cold agglutinins commonly have variable heavy-chain regions encoded by VH, with a distinct idiotype identified by the 9G4 rat murine monoclonal antibody.
• The best developed version of immune network theory is called the symmetrical network theory, in which the distinction between idiotype and paratope plays no role.
• Multiple other B cell antigens are being studied as targets, including CD22, CD23, ROR-1 and the immunoglobulin light-chain idiotype expressed by the individual cancer.
• "' Abagovomab "'is a mouse anti-idiotype monoclonal antibody whose variable epitope mirrors a tumour antigen ( CA-125 ) highly expressed in the epithelial ovarian cancer.
• So, when a full, high-fidelity copy of the idiotype is linked to a foreign protein ( KLH ), and administered with an immune-enhancing agent ( GM-CSF ), the resulting vaccine can mount a highly specific anti-lymphoma attack that  trains the body s own immune system to solely recognize the idiotype as a  foreign invader, thus stimulating and recruiting the patient s own immune system to destroy micro-pockets of cancer cells that may remain following chemotherapy and potentially target and destroy newly arising lymphoma cells, thus delaying or preventing cancer recurrence.
• So, when a full, high-fidelity copy of the idiotype is linked to a foreign protein ( KLH ), and administered with an immune-enhancing agent ( GM-CSF ), the resulting vaccine can mount a highly specific anti-lymphoma attack that  trains the body s own immune system to solely recognize the idiotype as a  foreign invader, thus stimulating and recruiting the patient s own immune system to destroy micro-pockets of cancer cells that may remain following chemotherapy and potentially target and destroy newly arising lymphoma cells, thus delaying or preventing cancer recurrence.