iduronate การใช้

• Iduronate 2-sulfatase is required for the lysosomal degradation of heparan sulfate and dermatan sulfate.
• Iduronate-2-sulfatase has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase.
• Some will receive a placebo while others will receive the company's proposed drug known as as iduronate-2-sulfatase, or I2S . The study's principal investigator is Dr . Joseph Muenzer, associate professor of pediatrics at the University of North Carolina at Chapel Hill.
• :Eliminative cleavage of polysaccharides containing 1, 4-linked D-glucuronate or L-iduronate residues and 1, 4-alpha-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends