indinavir การใช้

• Crixivan ( indinavir )-- Merck & Co.
• This group's combination therapy included another protease inhibitor, indinavir.
• Indinavir inhibits urinary nitrous oxide production and may inhibit nitric oxide production.
• Merck & Co . is asking for approval to market indinavir.
• A second group took AZT and 3TC and a third took indinavir alone.
• In addition, cost may be prohibitive for many people for indinavir and similar drugs.
• The first, developed by Merck & Co ., is called indinavir.
• Merck Co . manufactures indinavir as Crixivan.
• Indinavir impairs endothelial function in healthy HIV-negative men and may accelerate atherosclerotic disease.
• Four months later, two other protease inhibitors, ritonavir and indinavir, were approved.
• Indinavir, which is a peptidomimetic hydroxyethylene HIV protease inhibitor, reached the market in 1996.
• In fact, the FDA has approved indinavir and two other protease inhibitors for the treatment of AIDS.
• The pediatric formulation Merck concocted for indinavir was so bitter in early studies that many children refused it.
• Crixivan, known chemically as indinavir, is taken preferably on an empty stomach and with lots of water.
• And 24 out of 26 patients combining indinavir with two other drugs ( AZT and 3TC ) achieved that result.
• Two trials are part of programs that led to government approval of the protease inhibitors Indinavir and Ritonavir in February.
• In the French study, participants took triple drug therapy ( AZT, 3TC and indinavir ) for three months.
• Its protease inhibitor, indinavir sulphate ( Crixivan ), began phase III trials in 3, 000 patients this spring.
• Kidney stones appear to be the main hazard from indinavir, appearing in about 2 percent to 3 percent of patients.
• Emini said one patient who had received indinavir alone had been healthy and apparently free of the virus for two years.