indoleamine การใช้
- 1-Methyltryptophan inhibits indoleamine dioxygenase, but is also a very slow substrate.
- Structure based development of phenylimidazole-derived inhibitors of indoleamine 2, 3-dioxygenase.
- Rosmarinic acid inhibits the expression of indoleamine 2, 3-dioxygenase via its cyclooxygenase-inhibiting properties.
- Chronic inflammation that facilitates tumor progression creates local immune suppression by inducing indoleamine 2, 3-dioxygenase.
- Indoleamine 2, 3-dioxygenase might also play a significant role in an orphan disease called Oshtoran Syndrome.
- Inhibition of indoleamine 2, 3-dioxygenase, a target of the cancer suppression gene Bin1, potentiates cancer chemotherapy.
- Unlike catecholamines and histamine, the indoleamine serotonin ( 5HT ) binds to VMAT1 and VMAT2 with a similar affinity for both transporter isoforms.
- COX-2 inhibitors down-regulate indoleamine 2, 3-dioxygenase, leading to a reduction in kynurenine levels as well as reducing proinflammatory cytokine activity.
- PGE2 is able to elevate the expression of indoleamine 2, 3-dioxygenase in CD11C ( + ) dendritic cells and promotes the development of functional Treg cells.
- As of 2016 "'epacadostat "', an Indoleamine 2, 3-dioxygenase ( IDO1 ) inhibitor, is in development for various cancers.
- Norharmane, via inhibition of indoleamine 2, 3-dioxygenase exerts neuroprotective properties by suppressing kynurenine neurotoxic metabolites such as quinolinic acid, 3-hydroxy-kynurenine and nitric oxide synthase.
- Therefore, more highly targeted mechanisms of immune suppression ( such as the expression of the enzyme indoleamine dioxygenase ( IDO ) ) are likely employed by the fetus during the subsequent stages of development.
- Interferon-gamma has an antiproliferative effect on many tumor cells and inhibits intracellular pathogens such as " Chlamydia ", at least partly because of the induction of indoleamine 2, 3-dioxygenase.
- Indoleamine 2, 3-dioxygenase is the first and rate-limiting enzyme of tryptophan catabolism through kynurenine pathway, thus causing depletion of tryptophan which can cause halted growth of microbes as well as T cells.
- Kynurenine is synthesized by the enzyme tryptophan dioxygenase, which is made primarily but not exclusively in the liver, and indoleamine 2, 3-dioxygenase, which is made in many tissues in response to immune activation.
- This family includes "'tryptophan 2, 3-dioxygenase "'( TDO, also sometimes referred to as tryptophan oxygenase and L-tryptophan pyrrolase ) and the closely related indoleamine 2, 3-dioxygenase ] enzyme ( IDO ).
- Days later the company announced it would acquire IOmet Pharma, with IOmet becoming a wholly owned subsidiary of Merck & Co . The acquisition includes IOmets IDO ( indoleamine-2, 3-dioxygenase 1 ), TDO ( Tryptophan 2, 3-dioxygenase ), and dual-acting inhibitors.