lamins การใช้

• In the vertebrate genome, lamins are encoded by three genes.
• Depolymerization of the nuclear lamins leads to disintegration of the nuclear envelope.
• Traditionally, replication sites were fixed on spatial structure of chromosomes by nuclear matrix or lamins.
• He is known for his research on nuclear lamins and their associated proteins in health and disease.
• In the early embryonic stages of the chick, the only lamins present are B-type lamins.
• In the early embryonic stages of the chick, the only lamins present are B-type lamins.
• The nuclear envelope is a membranous structure containing large protein complexes supported by a network of nuclear lamins.
• In the latter case as well it is the B-type lamins that are expressed in the early stages.
• Laminopathies are caused, among other mutations, to mutations in LMNA, a gene that synthetizes lamins A and C.
• CAAX box containing proteins that are prenylcysteine methylated include Ras, GTP-binding proteins, nuclear lamins and certain protein kinases.
• Comparison of the lamins to vertebrate cytoskeletal IFs shows that lamins have an extra 42 residues ( six heptads ) within coil 1b.
• Comparison of the lamins to vertebrate cytoskeletal IFs shows that lamins have an extra 42 residues ( six heptads ) within coil 1b.
• Vertebrate lamins consist of two types, A and B . Through alternate splicing, this gene encodes three type A lamin isoforms.
• Lamins found on the cytosolic face of the membrane, such as emerin and nesprin, bind to the cytoskeleton to provide structural support.
• This proteolytic activity is performed by members of the caspase-protein family who cleave the lamins after aspartic acid ( Asp ) residues.
• The inability to adequately repair DNA damages when A-type lamins are defective is likely responsible for some of the aspects of premature aging.
• The presence of lamins in embryonic development is readily observed in various model organisms such as " Xenopus laevis ", the chick and mammals.
• Phosphorylation of the lamins by cyclin B1-Cdk1 causes them to dissociate, compromising the structural integrity of the nuclear envelope so that it breaks down.
• Towards the end of the cell cycle, the nuclear membrane is reformed, and around the same time, the nuclear lamina are reassembled by dephosphorylating the lamins.
• The Heun s results denied the traditional concepts, budding yeasts don't have lamins, and support that replication origins self-assemble and form replication foci.