leukotoxin การใช้

• Other epoxidized lipids include the 18-carbon leukotoxin and isoleukotoxin.
• This ( + ) and (-) optical mixture is often termed vernolic acid or when studied in plants and leukotoxin when studied in mammals.
• CYP2C9 may also metabolize linoleic acid to the potentially very toxic products, vernolic acid ( also termed leukotoxin ) and coronaric acid ( also termed isoleukotoxin ); these linoleic acid eoxides cause multiple organ failure and acute respiratory distress in animal models and may contribute to these syndromes in humans.
• It metabolizes "'1 ) "'arachidonic acid to its various epoxides, i . e ., the epoxyeicosatrienoic acids ( also termed EETs ); "'2 ) "'docosahexaenoic acid to its various epoxides, i . e . the epoxydocosapentaenoic acids ( also termed EDPs ); and "'3 ) "'linoleic acid to its various epoxides, i . e . vernolic acid ( also termed leukotoxin ) and coronaric acid ( also termed isoleukotoxin ).
• It metabolizes : "'1 ) "'arachidonic acid to various epoxyeicosatrienoic acids ( also termed EETs ); "'2 ) "'linoleic acid to 9, 10-epoxy octadecaenoic acids ( also termed vernolic acid, linoleic acid 9 : 10-oxide, or leukotoxin ) and 12, 13-epoxy-octadecaenoic ( also termed coronaric acid, linoleic acid 12, 13-oxide, or isoleukotoxin ); "'3 ) "'docosohexaenoic acid to various epoxydocosapentaenoic acids ( also termed EDPs ); and "'4 ) "'eicosapentaenoic acid to various epoxyeicosatetraenoic acids ( also termed EEQs ).
• It metabolizes arachidonic acid to the following eicosatrienoic acid epoxides ( termed EETs ) : 5, 6-epoxy-8Z, 11Z, 14Z-EET, 5, 6-epoxy-8Z, 11Z, 14Z-EET, 11, 12-epoxy-5Z, 8Z, 14Z-EET, and 14, 15-epoxy-5Z, 8Z, 11Z-EET . CYP2J2 also metabolizes linoleic acid to 9, 10-epoxy octadecaenoic acids ( also termed vernolic acid, linoleic acid 9 : 10-oxide, or leukotoxin ) and 12, 13-epoxy-octadecaenoic ( also termed coronaric acid, linoleic acid 12, 13-oxide, or isoleukotoxin ); docosahexaenoic acid to various epoxydocosapentaenoic acids ( also termed EDPs ); and eicosapentaenoic acid to various epoxyeicosatetraenoic acids ( also termed EEQs ).