lofexidine การใช้

• Lofexidine inhibits the release of norepinephrine in the central and peripheral nervous system, thereby reducing some of the withdrawal symptoms, but it has no documented effect on drug craving and endogenous opioid levels.
• "' Lofexidine "'( sold under the brand names : "'BritLofex "'and "'Kai Er Ding "') is an antihypertensive, but more commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal.
• Columbia University, in collaboration with the National Institute on Drug Abuse ( NIDA ), is undertaking a clinical trial that looks at the effects of combined pharmacotherapy on cannabis dependency, to see if lofexidine in combination with dronabinol is superior to placebo in achieving abstinence, reducing cannabis use and reducing withdrawal in cannabis-dependent patients seeking treatment for their marijuana use.