lysin การใช้
- Lysins for other dangerous microbes could be added to the sensing devices.
- A lysin-based anthrax detector is closer at hand.
- Catalytic domains are highly conserved in phage lysins of the same class.
- But the scientists have a prototype of a lysin-based anthrax detector.
- Many steps remain before a usable therapy can be developed from the lysin.
- The lysin is applied to the emerging bacteria, making them spill out their contents.
- Scientists at Rockefeller University see the gamma phage lysin as a powerful weapon against anthrax.
- In order to reach the cell wall, phage lysins have to cross the cell membrane.
- Autolysins and some phage lysins are examples of N-acetylmuramoyl-L-alanine amidases.
- Attack strains of anthrax can be made resistant to antibiotics, but not to lysin, Fischetti said.
- Schuch and colleagues reported that the enzyme, called PlyG lysin, kills anthrax bacteria in the laboratory.
- More well known proteins in this family include saposin-C, NK-lysin, and amoebopore.
- All other lysins are monomeric and comprise two C-terminal domain binds to the cell wall substrate.
- Lysins exhibit species-specific binding to their egg receptor, possibly through differences in charged surface residues.
- Though designed to pierce the wall from the inside, the lysin enzyme can also crumble it from outside.
- The lysin would be tested for toxicity in people and could then be stockpiled for use in an attack.
- Injected into the bloodstream, lysin could serve as a therapy even against anthrax strains made resistant to antibiotics.
- This is typical in many staphylococcal lysins as well as the streptococcal PlyC holoenzyme, which contains two catalytic domains.
- The prototypical holin is the lambda phage S protein, which assists the lambda phage R protein ( lysin ).
- This allows the lysin to be a quick and sensitive detector for anthrax spores that might be used in an attack.
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