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lysin การใช้

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  • Lysins for other dangerous microbes could be added to the sensing devices.
  • A lysin-based anthrax detector is closer at hand.
  • Catalytic domains are highly conserved in phage lysins of the same class.
  • But the scientists have a prototype of a lysin-based anthrax detector.
  • Many steps remain before a usable therapy can be developed from the lysin.
  • The lysin is applied to the emerging bacteria, making them spill out their contents.
  • Scientists at Rockefeller University see the gamma phage lysin as a powerful weapon against anthrax.
  • In order to reach the cell wall, phage lysins have to cross the cell membrane.
  • Autolysins and some phage lysins are examples of N-acetylmuramoyl-L-alanine amidases.
  • Attack strains of anthrax can be made resistant to antibiotics, but not to lysin, Fischetti said.
  • Schuch and colleagues reported that the enzyme, called PlyG lysin, kills anthrax bacteria in the laboratory.
  • More well known proteins in this family include saposin-C, NK-lysin, and amoebopore.
  • All other lysins are monomeric and comprise two C-terminal domain binds to the cell wall substrate.
  • Lysins exhibit species-specific binding to their egg receptor, possibly through differences in charged surface residues.
  • Though designed to pierce the wall from the inside, the lysin enzyme can also crumble it from outside.
  • The lysin would be tested for toxicity in people and could then be stockpiled for use in an attack.
  • Injected into the bloodstream, lysin could serve as a therapy even against anthrax strains made resistant to antibiotics.
  • This is typical in many staphylococcal lysins as well as the streptococcal PlyC holoenzyme, which contains two catalytic domains.
  • The prototypical holin is the lambda phage S protein, which assists the lambda phage R protein ( lysin ).
  • This allows the lysin to be a quick and sensitive detector for anthrax spores that might be used in an attack.
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