macrocytosis การใช้

• Features that support a diagnosis of DBA include the presence of congenital abnormalities, macrocytosis, elevated fetal hemoglobin, and elevated adenosine deaminase levels in red blood cells.
• While at birth, blood count is usually normal, macrocytosis / megaloblastic anemia, defined as unusually large red blood cells, is the first detected abnormality, often within the first decade of life ( median age of onset is 7 years ).
• Gastrointestinal diseases that may cause macrocytosis include celiac disease ( severe sensitivity to gluten from wheat and other grains that causes intestinal damage ) and Crohn s disease ( inflammatory bowel disease that can affect any part of the gastrointestinal tract ) . ( Source healthgrades . com)
• In addition, some evidence on macrocytosis in hypoxic stress ( when Epo can increase 1000-fold ) suggests that mitosis is actually " skipped " in later erythroid stages, when EpoR expression is low / absent, in order to provide emergency reserve of red blood cells as soon as possible.