merosin การใช้

• Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy.
• This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 ( merosin ) and laminin 4 ( s-merosin ).
• This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 ( merosin ) and laminin 4 ( s-merosin ).
• In skeletal muscle the dystroglycan complex works as a transmembrane linkage between the extracellular matrix and the cytoskeleton . [ alpha ]-dystroglycan is extracellular and binds to merosin Ras-related signal pathway, can interact with the cytoplasmic domain of dystroglycan.