metalloproteinases การใช้

• This protein may also be important in inhibition of matrix metalloproteinases.
• This gene belongs to the tissue inhibitor of metalloproteinases gene family.
• MiR-712 targets tissue inhibitor of metalloproteinases 3 ( TIMP3 ).
• The extracellular matrix is degraded by serine endopeptidases and metalloproteinases.
• Examples of such metalloproteinases are collagenases, gelatinases and stromelysins.
• MMP-1 is a major metalloproteinases for collagen degradation.
• A common family of hemotoxins are snake venom metalloproteinases.
• A special role is played by Matrix metalloproteinases.
• The body breaks down the old skin with enzymes called matrix metalloproteinases, or MMPs.
• It has also been shown as a stimulator of several matrix metalloproteinases ( MMPs ).
• This leads to local inflammation through the signalling of synovial cells to produce metalloproteinases and collagenase
• It is a known reversible inhibitor of thermolysin and is expected to inhibit other metalloproteinases.
• Plasmin mediates the degradation of the extracellular matrix either by itself or in conjunction with matrix metalloproteinases.
• Excess matrix metalloproteinases, which are released by leukocytes, may also cause wounds to become chronic.
• Melting ulcers reflect inappropriate collagenolysis of the corneal stroma, by matrix-metalloproteinases ( MMPs ).
• Invasion is accompanied by proteolysis of the ECM through activation of MMP14, MMP2 and MMP9 metalloproteinases.
• This is believed to disrupt the action of matrix metalloproteinases and thus minimise host mediated tissue destruction.
• The mechanism for MMP-3 is a variation on a larger theme seen in all matrix metalloproteinases.
• Disintegrins are split into 5 classes : small, medium, large, dimeric, and snake venom metalloproteinases.
• Examples include HIV-1 protease, racemases, ?-lactamases, metalloproteinases, cyclooxygenases and many others.