metarhodopsin การใช้

• Rh undergoes a conformational change into its active form, metarhodopsin.
• Finally, Metarhodopsin II is deactivated.
• Finally, arrestin, another protein, binds the phosphorylated metarhodopsin II, completely deactivating it.
• Metarhodopsin activates Gq, which in turn activates a phospholipase C? ( PLC? ) known as NorpA.
• Metarhodopsin II activates the G protein transducin ( G t ) to activate the visual phototransduction pathway.
• It is this pathway, where Metarhodopsin II is phosphorylated and bound to arrestin and thus deactivated, which is thought to be responsible for the S2 component of dark adaptation.
• When the calcium levels fall during phototransduction, the calcium dissociates from recoverin, and rhodopsin kinase is released, when it proceeds to phosphorylate metarhodopsin II, which decreases its affinity for transducin.