methylations การใช้

• These two dimethyls were not synthesized by two successive C-methylations.
• In this cancer, DERL3 methylations seems to mediate the Warburg Effect.
• These include methylations and pseudouridylations, guided by snoRNAs.
• Biosynthetically, ?-methylations of amino acids are highly unusual in natural products.
• These cells have CpG methylations near the gene that, in effect, silence gene transcription.
• Cytosine methylations change the amount of UV light absorption of the nucleotide base, creating pyrimidine dimers.
• Methylations can occur by the formation of an ether bond on hydroxyl groups forming O-methylated polyphenols.
• Thus, while pseudouridine and 2-O-methylations stabilize the local RNA structure, D does the opposite.
• Recently a novel method to map 2'- " O " ribose methylations by high throughput sequencing has been published.
• Methylations can also occur on directly on a carbon of the benzene ring like in the case of poriol, a C-methylated flavonoid.
• The PEMT enzyme converts phosphatidylethanolamine ( PE ) to phosphatidylcholine ( PC ) via three sequential methylations by S-adenosyl methionine ( SAM ).
• A series of enzymatic hydroxylations and methylations leads to coumaric acid, caffeic acid, ferulic acid, 5-hydroxyferulic acid and sinapic acid.
• A series of enzymatic hydroxylations and methylations leads to coumaric acid, caffeic acid, ferulic acid, 5-hydroxyferulic acid, and sinapic acid.
• PiRNAs appear to affect particular methyltransferases that perform the methylations which are required to recognise and silence transposons, but this relationship is not well understood.
• However, during development and formation of different tissues CpG island methylations and chromatin reorganizations which can cause the stable silencing or activation of particular genes.
• Almost all of the methylations from the parents are erased, first during gametogenesis, and again in early embryogenesis, with demethylation and remethylation occurring each time.
• One study listed 147 specific genes with colon cancer-associated hypermethylated promoters and 27 with hypomethylated promoters, along with the frequency with which these hyper / hypo-methylations were found in colon cancers.
• Inhibition of m 6 A methylation via pharmacological inhibition of cellular methylations or more specifically by siRNA-mediated silencing of the m 6 A methylase " Mettl3 " led to the elongation of the circadian period.
• Some miRNAs target the messenger RNAs for DNA methyltransferase genes " DNMT1 ", " DNMT3A " and " DNMT3B ", whose gene products are needed for initiating and stabilizing promoter methylations.
• Inhibition of m 6 A methylation via pharmacological inhibition of cellular methylations or more specifically by siRNA-mediated silencing of the m 6 A methylase " Mettl3 " led to the dramatic elongation of the circadian period.