methyltyramine การใช้

• N-methyltyramine hydrogen oxalate, C 9 H 13 NO . C 2 H 2 O 4 : m . p . 250 癈; very poorly soluble in water.
• Thus, replacement of the " N "-methyl group in synephrine with a hydrogen atom gives " N "-methyltyramine; replacement of the synephrine phenolic 4-OH group by a  H gives halostachine.
• Small amounts of metabolites ( alpha-methyldopa and alpha-methyldopamine ) were found after the administration of both single-doses and maintenance-doses of AMPT . Small amounts of methyltyramine and alpha-methylnoradrenaline were found in patients undergoing AMPT therapy.
• Hordenine has been found to be a potent stimulant of gastrin release in the rat, being essentially equipotent with N-methyltyramine : 83 nM / kg of hordenine ( corresponding to ~ 14 mg / kg of the free base ) enhancing gastrin release by ~ 60 %.
• While it does not contain mescaline like many other North American cactus species ( such as peyote ), it has been found to contain other centrally active substances, such as " N "-methyltyramine and hordenine, albeit in doses too small to be active.
• In Mexico, Aztekium ritterii it is called  Peyotillo .  However, even though it contains " N "-methyltyramine, hordenine, anhalidine, mescaline, pellotine, and 3-methoxytyramine, there have been no ethnobotanical reports that state that it has ever been used by native Indians.
• NMT was also made by Kirkwood and Marion starting from 4-methoxyphenethylamine, but this was first converted to the imine with benzaldehyde, followed by methylation with dimethyl sulfate; the product was converted to N-methyl-4-methoxyphenethylamine, and finally de-O-methylated with HBr to give N-methyltyramine.
• Chemically, hordenine is the " N "-methyl " N "-methyltyramine, and the " N ", " N "-dimethyl derivative of the well-known biogenic amine tyramine, from which it is biosynthetically derived and with which it shares some pharmacological properties ( see below ).
• In a survey of the ability of a wide range of arylalkylamines and their derivatives to release norepinephrine ( NE ) from mouse heart, Daly and co-workers determined that 10 mg hordenine sulfate did not cause any significant NE release, in contrast to the same doses of the closely related compounds N-methyltyramine hydrochloride ( which released 36 % over control ) and tyramine hydrochloride ( which released 50 % over control ).