mitomycin c การใช้

• Mitomycin C has also been used topically rather than intravenously in several areas.
• Fibrosis can be reduced by use of mitomycin C during surgery.
• When the mitomycin C, species-specific cellular aggregation is induced.
• And the cell-attacking chemical, mitomycin C, is a poison developed by a soil-dwelling microbe, Streptomyces lavendulae.
• Soon after, Medac focused on the indication area oncology and began marketing the pharmaceutical preparation Mitomycin C.
• Exposure of these organisms to the DNA damaging agents UV irradiation, bleomycin or mitomycin C induces species-specific cellular aggregation.
• Other compounds used in cancer chemotherapy that have the ability to form ICLs are cisplatin, mitomycin C, carmustine, and psoralen.
• The mitomycin C is a well-known chemotherapy agent that attacks dividing cells by entangling their DNA strands with chemical cross-links.
• Competence, in " S . pneumoniae ", is induced by DNA-damaging agents such as mitomycin C, a DNA inter-strand competence system.
• Mitomycin C may be used with surgery appears to reduce the risk of the problem returning but is associated with side effects.
• Mitomycin C has recently been found to have very good activity against persisters created by " Borrelia burgdorferi ", the causative agent of lyme disease.
• In rice ( " Oryza sativa " ), mutants with a defective " RAD51C " gene have increased sensitivity in somatic cells to mitomycin C.
• In 1956, " Streptomyces lavendulae " was found to produce an antibiotic called Mitomycin C, which has been studied for its cytotoxic effects on cancer cells.
• FANCG, involved in Fanconi anemia, confers resistance to both hygromycin B and mitomycin C . FANCG contains a 5-prime GC-rich untranslated region characteristic of housekeeping genes.
• A deficiency of FAN1 increases in vitro sensitivity to cisplatin and mitomycin C, two crosslinking agents FAN1 is also able to repair mitomycin C induced double strand breaks.
• A deficiency of FAN1 increases in vitro sensitivity to cisplatin and mitomycin C, two crosslinking agents FAN1 is also able to repair mitomycin C induced double strand breaks.
• Electromotive drug administration ( EMDA ) is also used in conjunction with mitomycin C to reduce the probability of recurrence of bladder cancer after surgical removal of the tumor.
• When the hyperthermophilic archaea " Sulfolobus solfataricus " and " Sulfolobus acidocaldarius " are exposed to the DNA damaging agents UV irradiation, bleomycin or mitomycin C, species-specific cellular aggregation is induced.
• The third is in esophageal and tracheal stenosis where application of mitomycin C onto the mucosa immediately following dilatation will decrease re-stenosis by decreasing the production of fibroblasts and scar tissue.
• Recombinational repair of DNA crosslinks also likely occurs in plants where it depends on gene " rad51 ", a " recA " paralog " XRCC3 " are hypersensitive to mitomycin C, a crosslinking agent.