mpgn การใช้

• MPGN frequently progresses to end-stage renal disease ( ESRD ) and disease recurrence following kidney transplantation.
• MPGN accounts for approximately 4 % of primary renal causes of nephritic syndrome in children and 7 % in adults.
• Spontaneous remissions of MPGN II are rare, approximately half of those affected with MPGN II will progress to end stage renal disease within 10 years.
• Spontaneous remissions of MPGN II are rare, approximately half of those affected with MPGN II will progress to end stage renal disease within 10 years.
• Membranoproliferative glomerulonephritis ( MPGN, previously known as mesangiocapillary glomerulonephritis ) is an uncommon cause of chronic nephritis that primarily affects children but can occur at any age.
• Evidence also shows that sufferers of MPGN type II kidney disease can develop retinal abnormalities including CSR caused by deposits of the same material that originally damaged the glomerular basement membrane in the kidneys.
• In many cases, people with MPGN II can develop drusen which is caused by same deposits within the Bruch's membrane beneath the retinal pigment epithelium ( RPE ) layer of the eye.
• Dense-deposit disease ( DDD ), previously considered a subtype of MPGN ( sometimes known as MPGN II ), is characterized by dense deposits of immunoglobulins, complement factors, or both in the basement membrane of the glomerulus.
• Dense-deposit disease ( DDD ), previously considered a subtype of MPGN ( sometimes known as MPGN II ), is characterized by dense deposits of immunoglobulins, complement factors, or both in the basement membrane of the glomerulus.
• Canadian researchers have reported a case in which eculizumab produced  a dramatic response in a 16-year-old girl with MPGN, as evidenced by amelioration of neurologic complications, normalization of kidney function, and improvements in thrombocytopenia, anemia, proteinuria, and hypoalbuminemia.