myotubes การใช้

• Muscle fibers generally form from the fusion of myoblasts into multi-nucleated fibers called myotubes.
• When the growth factor runs out, the myoblasts cease division and undergo terminal differentiation into myotubes.
• The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes.
• Finally, he succeeded _ at least in a lab experiment using mouse muscle cell structures called myotubes.
• MyoD and Myf5 enable the differentiation of myogenic progenitors into myoblasts, followed by myogenin, which differentiates the myoblast into myotubes.
• Decorin is released from contracting human myotubes, and circulating decorin levels are increased in response to acute resistance exercise in humans.
• In summary, our findings suggest that decorin secreted from myotubes in response to exercise is involved in the regulation of muscle hypertrophy and hence could play a role in exercise-related restructuring processes of skeletal muscle ."
• Ectopic expression of JDP2 inhibits the retinoic acid-induced differentiation of F9 cells By contrast, JDP2 induces terminal muscle cell differentiation in C2 myoblasts and reduces the tumorigenicity of rhabdomyosarcoma cells and restored their ability to differentiate into myotubes.
• Systems approach using high-throughput sequencing and ChIP-chip analysis has been essential in elucidating the targets of myogenic regulatory factors like MyoD and myogenin, their inter-related targets, and how MyoD acts to alter the epigenome in myoblasts and myotubes.
• Accordingly, myonectin transcript was up-regulated by compounds ( forskolin, epinephrine, ionomycin ) that raise cellular cAMP or calcium levels . . . . In vitro results of myonectin expression in myotubes suggest that exercise-induced rises in intracellular calcium levels may also up-regulate myonectin expression in intact skeletal muscle . . . . Consistent with enhanced mRNA expression in skeletal muscle of mice subjected to voluntary exercise, circulating levels of myonectin also increased, suggesting a potential role of myonectin in exercise-induced physiology.