nitrazepam การใช้

• Nitrazepam is sometimes tried to treat epilepsy when other medications fail.
• Nitrazepam at doses of 5 mg or higher impairs driving skills
• Therefore, benzodiazepines including nitrazepam should be avoided during pregnancy.
• These results reflect the long-acting nature of nitrazepam.
• Therefore, nitrazepam can be taken with or without food.
• Nitrazepam, however, caused more profound abnormalities than chlordiazepoxide.
• The use of nitrazepam during pregnancy can lead to intoxication of the newborn.
• Breast feeding by mothers using nitrazepam is not recommended.
• Nitrazepam is recommended to be avoided in patients who drive or operate machinery.
• Clonazepam is a chlorinated derivative of nitrazepam and therefore a chloro-nitro benzodiazepine.
• Nitrazepam rapidly crosses the placenta and is present in breast milk in high quantities.
• Nitrazepam is not recommended during pregnancy as it is associated with causing a neonatal withdrawal syndrome
• Nitrazepam and flunitrazepam were significantly more commonly implicated in suicide related deaths than natural deaths.
• Nitrazepam and temazepam were the most prevalent drugs detected, followed by oxazepam and flunitrazepam.
• As with other hypnotic drugs, nitrazepam is associated with an increased risk of traffic accidents.
• Benzodiazepines and in particular nitrazepam and flunitrazepam should therefore be prescribed with caution in the elderly.
• Concomitant food intake has no influence on the rate of absorption of nitrazepam nor on its bioavailability.
• In Australia, nitrazepam and temazepam were the benzodiazepines most commonly detected in overdose drug related deaths.
• The photic driving response elicited by a flash light in the visual cortex is also suppressed by nitrazepam.
• Use of benzodiazepines such as nitrazepam in late pregnancy in especially high doses may result in floppy infant syndrome.