nonhistone การใช้

• She continued to isolate and characterize nonhistone chromosomal proteins but started studying Drosophila.
• HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins.
• As far back as the early 1970s, receptor-associated nonhistone proteins were known to support the function of nuclear receptors.
• High mobility group A ( HMGA ) proteins, characterized by an AT-hook, are small, nonhistone, chromatin-associated proteins that can modulate transcription.
• Song, Xiaoyuan, et al . " The nonhistone, N-terminal tail of an essential, chimeric H2A variant regulates mitotic H3-S10 dephosphorylation . " Genes & Development 26.6 ( 2012 ) : 615-629.
• Therefore, a new extraction procedure was developed in 1993 to increase recovery of nonhistone proteins using a ( NUN ) solution containing 0.3 M "'N "'aCl, 1 M "'u "'rea, and 1 % nonionic detergent "'N "'onidet P-40, which destabilize salt bridges, hydrogen bonds, and hydrophobic interactions, respectively; resulting in a disruption of interaction between proteins and DNA . By incubating nuclei in NUN buffer and centrifuging the solution, the supernatant will therefore contain nuclear proteins.