nonionized การใช้

• The metformin pKa values make metformin a stronger base than most other basic drugs with less than 0.01 % nonionized in blood.
• Furthermore, the lipid solubility of the nonionized species is slight as shown by its low logP value ( log ( 10 ) of the distribution coefficient of the nonionized form between octanol and water ) of-1.43.
• Furthermore, the lipid solubility of the nonionized species is slight as shown by its low logP value ( log ( 10 ) of the distribution coefficient of the nonionized form between octanol and water ) of-1.43.