norleucine การใช้

• Like most other ?-amino acids, norleucine is chiral.
• It could be classified as a cyclic derivate of norleucine, having two hydrogen atoms less.
• Norleucine is also a popular internal standard for the analysis of amino acids via GC-MS.
• In 1913, in collaboration with Emil Abderhalden ( 1877 1950 ) he isolated an alpha-amino acid known as norleucine.
• "' 6-Diazo-5-oxo-L-norleucine "'( DON ) is a glutamine diazo compound was characterized in 1956 by Henry W Dion et al ., who suggested a possible use in cancer therapy.
• The study hypothesized, and another found correlating evidence, that the most likely mechanism of getting from the ?-dicarbonyl to glucosepane is through the intramolecular aldimine 6-( 3, 4-dihydroxy-6-oxo-3, 4, 5, 6-tetrahydro-2H-azepinium-1-yl ) norleucine.