nortriptyline การใช้

• A nortriptyline overdose is considered a medical emergency and frequently results in death.
• Nortriptyline ( brand name Pamelor ) is one of the oldest drugs called tricyclics.
• If use of nortriptyline is warranted, therapeutic drug monitoring is recommended to guide dose adjustments.
• In the short term; however, nortriptyline may disturb sleep due to its activating effect.
• The authors of a review noted that the nortriptyline group had more episodes prior to treatment.
• However, fewer and milder side effects occur with nortriptyline than tertiary tricyclic antidepressants such as imipramine and amitriptyline.
• Nortriptyline should not be used in the acute recovery phase after myocardial infarction ( viz, heart attack ).
• Like other tricyclic antidepressants, nortriptyline also blocks sodium channels, possibly accounting in part for its analgesic action.
• Unlike the TCAs clomipramine and imipramine, concurrent use of nortriptyline with MAO inhibitors is safe within recommended dosage ranges.
• For this reason, nortriptyline is preferred to other tricyclic antidepressants, particularly with older adults, which also improves compliance.
• A study with men has found that treatment with nortriptyline is associated with higher risk of suicidal ideation compared to escitalopram.
• Most individuals ( about 77-92 % ) are extensive metabolizers, and have " normal " metabolism of nortriptyline.
• Traditionally, tricyclic antidepressants ( TCAs ), such as nortriptyline, have been used in the treatment of post-stroke depression.
• Ultrarapid metabolizers use nortriptyline much faster than extensive metabolizers; patients with this metabolizer type may have a greater chance of experiencing pharmacological failure.
• In a comparison group, 60 other patients were treated with nortriptyline, one of the older class of antidepressant drugs, known as tricyclics.
• If the anti-seizure drugs are found ineffective, one of the tricyclic antidepressant medications such as amitriptyline or nortriptyline, may be used.
• Hogg had been treated for more than one and a half years for depression, undergoing counseling and taking the drugs Prozac and Nortriptyline, Walker said.
• Recently, an evidence-based guideline sponsored by the International Association for the Study of Pain recommends nortriptyline as a first-line medication for neuropathic pain.
• These include the alpha-2 agonists ( clonidine and guanfacine ), tricyclic antidepressants ( desipramine and nortriptyline ), and newer antidepressants ( bupropion and venlafaxine ).
• "' Nortriptyline "'is a second-generation tricyclic antidepressant ( TCA ) marketed as the hydrochloride major depression and childhood nocturnal enuresis ( bedwetting ).